Bone morphogenetic protein-2 enhances Wnt/β-catenin signaling-induced osteoprotegerin expression

Blocking c-Met signaling enhances bone morphogenetic protein-2-induced osteoblast differentiation

We previously demonstrated that blocking hepatocyte growth factor (HGF) receptor/c-Met signaling inhibited arthritis and articular bone destruction in mouse models of rheumatoid arthritis (RA). In the present study, we investigated the role of c-Met signaling in osteoblast differentiation using the C2C12 myoblast cell line derived from murine satellite cells and the MC3T3-E1 murine pre-osteobla...

Bone Morphogenetic Protein Signaling Protects against Cerulein-Induced Pancreatic Fibrosis

Bone morphogenetic proteins (BMPs) have an anti-fibrogenic function in the kidney, lung, and liver. However, their role in chronic pancreatitis (CP) is unknown. The aim of this study was to define the anti-fibrogenic role of BMP signaling in the pancreas in vivo under CP induction. Mice with a deletion of BMP type II receptor (BMPR2(+/-)) were used in this study in comparison with wild-type mic...

Regulates Early Thymocyte Differentiation Bone Morphogenetic Protein 2/4 Signaling

Cyclic stretch enhances bone morphogenetic protein-2-induced osteoblastic differentiation through the inhibition of Hey1

Substantial evidence has indicated that osteoblastic differentiation may be regulated by mechanical loads or bone morphogenetic protein-2 (BMP-2). BMP-2-induced in vivo osteogenesis can be significantly enhanced in the presence of mechanical stimuli, revealing the therapeutic potential of the combined application of BMP-2 and mechanical loads in clinical bone diseases (e.g., bone fractures and ...

Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.

RATIONALE Matrix Gla protein (MGP) is a calcification inhibitor, which binds and inhibits bone morphogenetic protein (BMP)-2 and -4. OBJECTIVE The objective was to determine whether MGP also binds other proteins, which could interfere with its function. METHODS AND RESULTS We transfected bovine aortic endothelial cells with N-terminally FLAG-tagged MGP and used immunoprecipitation and liqui...